Publications

Automatic quantification of HER2 gene amplification in invasive breast cancer from chromogenic in situ hybridization whole slide images

Md Shakhawat Hossain, Matthew G Hanna, Naohiro Uraoka, Tomoya Nakamura, Marcia Edelweiss, Edi Brogi, Meera R Hameed, Masahiro Yamaguchi, Dara S Ross, Yukako Yagi

Journal of Medical Imaging , Vol. 6 (4)

Human epidermal growth factor receptor 2 (HER2), a transmembrane tyrosine kinase receptor encoded by the ERBB2 gene on chromosome 17q12, is a predictive and prognostic biomarker in invasive breast cancer (BC). Approximately 20% of BC are HER2-positive as a result of ERBB2 gene …